Bone fracture is a major complication of osteoporosis that results when loss of calcium and phosphate increased the fragility of bones. Estrogen deficiencies result from menopause and not osteoporosis. Calcium and vitamin D supplements may be used to support normal bone metabolism, But a negative calcium balance isnâ€™t a complication of osteoporosis. Dowagerâ€™s hump results from bone fractures. It develops when repeated vertebral fractures increase spinal curvature.